Regular captain Wilfred Ndidi will miss the game after picking up a suspension due to card accumulation.
Ndidi received his first booking in Nigeria’s Round of 16 victory over Mozambique and was cautioned again in the quarter-final against Tunisia.
Osimhen, who was appointed vice-captain ahead of the tournament, previously wore the armband in Nigeria’s final group-stage match against Uganda.
The striker’s leadership is expected to be crucial as the Super Eagles aim to secure a spot in the AFCON final, building on a strong campaign so far.
