The reported resignation was announced Wednesday by Church Gist, a media platform owned by Pastor Leke Beecroft, one of the long-term pastoral assistants at the LFC Headquarters in Ota.
Isaac is said to be planning to commence a new church ministry.
It will be recalled that Pastor Isaac was announced in September as the national youth pastor of the Youth Alive Fellowship (YAF), the youth arm of the church.
Youth Alive Fellowship announced this via its official Facebook page, adding that the new youth pastor will take the youthful congregation to glorious heights.
“On the behalf of the Youths of Living Faith Church Worldwide, we say a big welcome to our National Youth Pastor, Pastor Isaac Oyedepo as he takes the Youth Alive Fellowship to the next levels of glory,” YAF posted.
Isaac took over from his predecessor, Pastor David Nwabueze, who has been transferred to LFC Nasarawa state.
In a recent interview, Isaac said his purpose in life was “to reclaim a generation and to ensure that this generation sees the fire God’s revival in our generation.”
Isaac was ordained as Living Faith Church pastor by American preacher Kenneth Copeland in May 2007.
He has pastored the Winners Chapel International, South Africa, Maryland United States and Lokogoma, Abuja before he was redeployed to the headquarters, Canaanland Ota.
He is married to Ayomitide Omogbadegun and they are blessed with children.
Isaac graduated from Oral Roberts University, US, while his elder brother David Jnr currently serves as Resident Pastor of Faith Tabernacle, at the LFC Headquarters in Ota.